Acanthosis nigricans is characterized by velvety, brown-black plaques, typically located in the axilla and neck.
It is associated with:
- Insulin-resistance:
- Diabetes
- Acromegaly
- Cushing syndrome
- Hypothyroidism
- PCOS
- Malignancy – especially gastric adenocarcinoma
- Other
- Primary biliary cirrhosis
- Prader-Willi syndrome
- Medications
- Glucocorticoids
- OCP
- Niacin
Management
- Treat underlying cause
- ? retinoids
