Kallmann syndrome is the combination of hypogonadotropic hypogonadism and anosia.
It may be inherited in a X-linked recessive, autosomal dominant or autosomal recessive pattern. However, most cases are sporadic.
Associations with the x-linked recessive form of Kallmanns include
- Unilateral renal aplasia - 30%
- Bimanual synkinesis (upper limb mirror movements) – 75%
Blood LH/FSH/testosterone are all either normal or low.
Treatment is with hormone replacment, which restores fertility in the vast majority of patients.
