A Holmes-Adie pupil is one that:
  • often appears large
  • reacts poorly to light
  • accommodates to a normal degree but more slowly ('tonic' pupil)

If dilute muscarinic agonists are applied it constricts promptly (whereas they would have little effect on a normal eye)

Holmes-Adie Syndrome is a Holmes-Adie pupil plus tendon areflexia.

The condition occurs most commonly in young women and is essentially benign.

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