Alport’s syndrome is an inherited disorder of type IV collagen, predominantly affecting the kidneys.
Features of Alport's syndrome are:
- Abnormal basement membrane –“basket-weave” pattern
- Haematuria – microscopic with occasional macroscopic
- Proteinuria
- Nephritis
- Renal failure – mainly in males
- Hypertension
- Sensorineural deafness – 55%
- Ocular abnormalities
- Anterior lenticonus – pathogomonic
- Retinal flecks
Males with Alport’s syndrome are more severely affected than females.
Treatment is symptomatic and ?renal transplant.
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