Pick’s disease

Pick’s disease is the eponym for frontotemporal dementia

Characteristics of frontotemporal dementia include: 
  • Insidious onset and gradual progression 
  • Decline in social skills and loss of inhibitions 
  • Emotional blunting 
  • Loss of insight
  • Loss of language skills 
  • Onset before age 65 

Whereas in other forms of dementia memory is impaired, in frontotemporal dementia memory remains intact. 

The histological feature of frontotemporal dementia is tau-positive neuronal cytoplasmic inclusions. 

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